10.03.2008 20:03:00
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USANA Demonstrates That Symptoms of Metabolic Syndrome Can Be Improved
USANA Health Sciences, Inc. (NASDAQ: USNA) announced today that a large,
third-party clinical study recently completed at the University of
Colorado Denver (UCD) has confirmed that lifestyle change, involving
diet, supplementation and exercise, can improve the metabolic syndrome.
The results of this study verified those from an earlier study conducted
by USANA in 2005. Both clinical trials employed a lifestyle program that
included exercise, USANA’s nutritional
supplements, and a low-glycemic diet including USANA’s
nutritional shakes and bars. Metabolic syndrome is a pre-diabetic state
that involves multiple symptoms including central obesity, insulin
resistance, elevated blood lipids, elevated blood glucose, and high
blood pressure. Dr. Ray Strand, a family-practice physician, member of
USANA’s Scientific Advisory Council and
distributor, developed the Internet-based lifestyle program.
USANA’s original study, conducted with 25
subjects, found that the lifestyle modification program had dramatic
effects on the health of participants. The University of Colorado study
used a larger group (n=60) and found similar results. Those results will
be fully published later this year, however initial results from the
study are promising.
Subjects in the UCD study lost an average of 12 pounds over the 12-week
program.
Even more dramatic, however, were the significant improvements in
measures of glycemic control, cardiovascular health, inflammation and
antioxidant status.
On average, study participants who completed the study (n=53) achieved
the following transformations of measures of glycemic control:
Fasting insulin was reduced by 32 percent
Insulin levels during an oral glucose tolerance test at 120 min
decreased by 44 percent
Insulin resistance as measured by the HOMA index decreased by 32
percent
There also were notable changes in the subjects’
measures of cardiovascular health:
Systolic blood pressure declined 6 percent
Diastolic blood pressure dropped 8 percent
Total cholesterol dropped 5 percent
Fasting triglyceride levels dropped 16 percent
Markers of inflammation and antioxidant status were also considerably
improved:
Plasma Antioxidant Reserve (PAR) increased 20 percent
Urinary Isoprostanes, a marker of lipid peroxidation due to oxidative
stress, decreased 29 percent
C-Reactive Protein (CRP), a marker of inflammation, dropped 27 percent
Vitamin E alpha levels increased by 30 percent
All of these changes are consistent with improvements to markers of
Metabolic Syndrome and with significant improvements in cardiovascular
and metabolic health.
Holly Wyatt, a physician and faculty member of the University of Colorado’s
Department of Medicine, Division of Endocrinology, Metabolism and
Diabetes, oversaw the university study. "This
is a very promising program that produced some very positive changes in
the cardiovascular risk factors associated with the metabolic syndrome,”
Dr. Wyatt said. "The shifts in dietary habits
to calorically restricted low-glycemic meals and the modest increases in
physical activity were not only effective but also are realistic
behavioral changes many people can make.” About USANA
USANA Health Sciences develops and manufactures high-quality
nutritionals, personal care, and weight management products that are
sold directly to Preferred Customers and Associates throughout the
United States, Canada, Australia, New Zealand, Hong Kong, Japan, Taiwan,
South Korea, Singapore, Malaysia, Mexico, the Netherlands and the United
Kingdom.
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