The Medicines Company to Announce Third Quarter 2008 Financial Results on Wednesday, October 22, 2008

The Medicines Company (NASDAQ: MDCO) has scheduled its quarterly conference call for Wednesday, October 22, 2008 at 8:30 a.m. Eastern Time to discuss third quarter 2008 financial results and operational developments.

The conference call will be available via phone and webcast. The dial in information is listed below:

Domestic Dial In: 877-719-9795

International Dial In: 719-325-4749

Replay is available from 11:30 a.m. Eastern Time following the conference call through November 5, 2008. To hear a replay of the call dial 888-203-1112 (domestic) and 719-457-0820 (international). Passcode for both dial in numbers is 1432418.

This call is being webcast and can be accessed at The Medicines Company website at www.themedicinescompany.com.

MDCO-G

The Medicines Company (NASDAQ: MDCO) is focused on advancing the treatment of critical care patients through the delivery of innovative, cost-effective medicines to the worldwide hospital marketplace. The Company markets Angiomax^® (bivalirudin) in the United States and other countries for use in patients undergoing coronary angioplasty, and Cleviprex™ (clevidipine butyrate) injectable emulsion in the United States for the reduction of blood pressure when oral therapy is not feasible or not desirable. The Company also has an investigational antiplatelet agent, cangrelor, in late-stage development and a serine protease inhibitor, CU-2010, in early-stage development. The Company's website is www.themedicinescompany.com.