Sosei Subsidiary Heptares Awarded $5.5 Million Research & Development Grant from the US National Institute on Drug Abuse

Sosei Group Corporation ("Sosei”; TOKYO:4565) is pleased to announce that its wholly-owned subsidiary Heptares Therapeutics ("Heptares”) has been awarded a grant from the National Institute on Drug Abuse (NIDA), one of the US National Institutes of Health. The grant of approximately $5.5 million, with additional funding from Heptares, will support a three-year research project aimed at developing a selective antagonist for the human Orexin-1 receptor for use in treating cocaine addiction and dependence, for which there are currently no approved treatments.

The Orexin-1 receptor has been implicated in modulating cravings for a number of substances including cocaine, and antagonists of the receptor have been shown to be effective in models of cocaine addiction and dependence. Supported by the grant from NIDA, Heptares will progress lead molecules it has already identified to be selective antagonists of the Orexin-1 receptor to selection of a candidate drug, and then take this molecule through pre-clinical development. This project will be supported by the Heptares GPCR structure-based development platform, in particular making use of high-resolution X-ray structures Heptares has obtained of molecules bound to the closely related Orexin-1 and Orexin-2 receptors.

Fiona Marshall, Heptares Chief Scientific Officer and co-founder, said: "We are delighted to receive this grant award from NIDA. Blockade of the Orexin-1 receptor offers a new approach to target craving and relapse associated with drugs of abuse such as cocaine. We are using our structure based design approaches to identify and optimise highly selective Orexin-1 antagonists, and with the help of this grant from NIDA we intend to progress these through to clinical development.”

The research is supported by the National Institute on Drug Abuse (NIDA) of the US National Institutes of Health, under Grant Number R01DA039553-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Notes to Editors:

About Sosei
Sosei is a biopharmaceutical company originating from Japan but with global presence. Sosei’s primary business model is based on identifying novel and/or differentiated product assets or technology platforms and, through supporting these in preclinical and clinical development and establishing commercial partnerships, advancing new medicines to patients worldwide. For more information about Sosei, please visit www.sosei.com/en/.

About Heptares Therapeutics
Heptares is a clinical-stage company creating transformative medicines targeting G protein-coupled receptors (GPCRs), a superfamily of 375 receptors linked to a wide range of human diseases. Its proprietary structure-based drug design technology enables Heptares to engineer drugs for highly validated, yet historically undruggable or challenging, GPCRs. Using this approach, Heptares has built an exciting pipeline of new medicines with the potential to transform the treatment of Alzheimer’s disease, schizophrenia, migraine, addiction, metabolic disease, and other indications. Heptares pharmaceutical partners include AstraZeneca, MedImmune, Cubist, MorphoSys and Takeda. Heptares is a wholly owned subsidiary of Sosei Group Corporation. For more information, please visit www.heptares.com and www.sosei.com/en/.
HEPTARES is a registered trademark in the EU, Switzerland, US and Japan;
StaR^® is a registered trademark in the EU and Japan.

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