Ipsen S.A.: Disclosure of Trading in Own Shares

Regulatory News: Ipsen Company declares (Paris:IPN) (Euronext: FR0010259150; IPN) the following purchase of it own shares realized on December 2007. IPSEN S.A. a french company with a registered share capital of 84 043 183 € Registered office 42 rue du docteur Blanche 75016 Paris – France Registered at the Paris Commercial and Companies Registry under number 419 838 529 RCS Paris Pursuant to applicable law on share repurchases, Ipsen S.A. declares the following purchase of it own shares on December 2007     Number of shares purchased(1)   Weighted Average Price (in €)   Amount (in €) 18/12/2007   Purchase   25,000   39.9029 €   997,572.50 € 19/12/2007   Purchase   25,000   39.8428 €   996,070.00 € 20/12/2007   Purchase   24,496   40.0725€   981,615.96 € 21/12/2007   Purchase   23,504   40.8687 €   960,577.92 € 24/12/2007   Purchase   16,000   41.1664 €   658,662.40 € 27/12/2007   Purchase   11,000   41.4993 €   456,492.30 € Total   Purchase   125,000   40.407 €   5,050,991.08 € (1) including the shares purchased by deritative financial instruments. About Ipsen Ipsen is an innovation driven international specialty pharmaceutical group with over 20 products on the market and a total worldwide staff of nearly 4,000. The company’s development strategy is based on a combination of products in targeted therapeutic areas (oncology, endocrinology and neuromuscular disorders) which are growth drivers, and primary care products which contribute significantly to its research financing. This strategy is also supported by an active policy of partnerships. The location of its four Research and Development centres (Paris, Boston, Barcelona, London) gives the Group a competitive edge in gaining access to leading university research teams and highly qualified personnel. In 2006, R&D expenditure was €178.3 million, i.e. 20.7% of consolidated sales, which amounted to €861.7 million while total revenues amounted to €945.3 million (in IFRS). 700 people in R&D are dedicated to the discovery and development of innovative drugs for patient care. Ipsen’s shares are traded on Segment A of Eurolist by EuronextTM (stock code: IPN, ISIN code: FR0010259150). Ipsen’ s shares are eligible to the "Service de Règlement Différé” ("SRD”) and the Group is part of the SBF 250 index. From 24 December 2007, the Group will be part of the SBF120 index. For more information on Ipsen, visit our website at www.ipsen.com. Forward-looking statements The forward-looking statements and targets contained herein are based on Ipsen's management's current views and assumptions. Such statements involve known and unknown risks and uncertainties that may cause actual results, performance or events to differ materially from those anticipated herein. Moreover, the Research and Development process involves several stages at each of which there is a substantial risk that the Group will fail to achieve its objectives and be forced to abandon its efforts in respect of a product in which it has invested significant sums. Therefore, the Group cannot be certain that favourable results obtained during pre-clinical trials will be confirmed subsequently during clinical trials, or that the results of clinical trials will be sufficient to demonstrate the safe and effective nature of the product concerned, or that the regulatory authorities will be satisfied with the data and information provided by the Company. Ipsen expressly disclaims any obligation or undertaking to update or revise any forward looking statements, targets or estimates contained in this press release to reflect any change in events, conditions, assumptions or circumstances on which any such statements are based, unless so required by applicable law. Ipsen's business is subject to the risk factors outlined in its information documents filed with the French Autorité des Marchés Financiers.