Given Imaging Reports Clinical Benefit Of PillCam SB In Crohn's Patients

(RTTNews) - Given Imaging (GIVN) announced new studies validating PillCam SB's role in improving care, management and outcomes for patients with known or suspected Crohn's disease.

"PillCam SB is one of the most important tools we have for detecting and monitoring small bowel diseases, such as Crohn's disease. Due to the evolving nature of Crohn's disease, it's crucial that we monitor mucosal healing, as well as disease progression, so that we are able to continually improve the targeting of our treatment regimens," said Neel Mann, M.D., Associate Director, Small Bowel Enteroscopy, Cedars-Sinai Medical Center.

The study's authors concluded that PillCam SB helped to re-classify disease phenotype in more than 60% of patients with suspected Crohn's disease or unclassified Inflammatory Bowel Disease, thereby potentially changing the management as well as the natural outcomes of small bowel Crohn's disease. More importantly, capsule endoscopy demonstrated mucosal healing in 70% patients, after assessment of therapy, positively changing disease outcome and achieving therapeutic goals in patients with non-stricturing phenotype Crohn's disease.

The company said the results of retrospective cross-sectional study of patients with established Crohn's disease showed that as a result of PillCam SB findings, 67% of patients had a change in management, including escalation in therapy, referral for surgery, de-escalation of anti-inflammatory therapy or initiation of therapy for concomitant IBS. Investigators concluded that PillCam SB, a safe and valuable tool in disease evaluation and management, had a significant impact on managing treatment options for patients with established Crohn's disease.

Crohn's disease is a chronic condition that causes inflammation in the lining of the small intestine wall and can affect any part of the digestive tract. Symptoms can include diarrhea, abdominal pain, weight loss and rectal bleeding.

The PillCam SB capsule is a minimally invasive procedure to visualize and monitor small bowel abnormalities associated with Crohn's disease, iron deficiency anemia (IDA) and obscure GI bleeding (OGIB).