16.07.2008 12:30:00
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Embryome Sciences, Inc. Acquires Exclusive License for ACTCellerate Technology
Embryome Sciences, Inc., a wholly owned subsidiary of BioTime, Inc.,
(OTCBB:BTIM) has acquired from Advanced Cell Technology, Inc. ("ACT”)
an exclusive license to use "ACTCellerate™”
embryonic stem cell technology and a bank of over 140 diverse progenitor
cell lines derived using that technology.
ACTCellerate™ is a recently discovered
technology that allows the rapid isolation of novel highly purified
embryonic progenitor cells. Embryonic progenitors are cells intermediate
between embryonic stem cells and fully differentiated cells. The
progenitor cells are relatively easy to manufacture on a large scale and
in a purified state, which may make it advantageous to work with these
cells compared to the direct use of embryonic stem cells. Using the
ACTCellerate platform technology over 140 distinguishable novel
progenitor cell lines have already been created, scaled-up, and banked.
These unique cell lines may possess the ability to become a wide array
of products never before available to the medical community, with
potential applications in research, drug discovery, and human
regenerative stem cell therapy. Embryome Sciences plans to sell the
progenitor cells, and the specific culture media that stimulates the
propagation of the cells, to the research community through the company’s
website Embryome.com. The company
may also collaborate with others in the development of human therapeutic
uses of the cell lines.
The licensed ACTCellerate rights include pending patent applications,
know-how, and the existing bank of cell lines. The license is exclusive
and world-wide for all commercial purposes, including the development of
research products and therapeutic and diagnostic products for human and
veterinary use. Embryome Sciences will pay ACT a license fee and an 8%
royalty on sales of products, services, and processes that utilize the
licensed technology. Once a total of $1,000,000 of royalties has been
paid, no further royalties will be due.
ACT has an option to reacquire rights to use the ACTCellerate technology
for the development of certain types of stem cells for human therapeutic
use in fields related to its core business.
"There is a large and growing market in
supplying basic research tools to scientists funded by the $3 billion
California stem cell initiative as well as scientists entering the field
world wide, and our long-term plan is to be the first profitable company
in the stem cell sector,” said Michael D.
West, Ph.D., CEO of BioTime and Embryome Sciences. "We
are already offering our first research products through our website
Embryome.com, where researchers can also access our stem cell database.
Our license of the ACTCellerate technology adds to our portfolio of
embryonic stem cell patent licenses that includes the core technology
from the Wisconsin Alumni Research Foundation, and other technology
sublicensed from Lifeline Cell Technology, LLC, which we plan to use to
develop and market additional stem cell research products.”
Embryome Sciences is presently marketing cell growth media called ESpanTM
in collaboration with Lifeline. These growth media are designed for the
growth of human embryonic progenitor cells. Additional new products that
Embryome Sciences has targeted for development are ESpyTM
cell lines, which will be derivatives of hES cells that send beacons of
light in response to the activation of particular genes. The ESpy™
cell lines will be developed in conjunction with Lifeline using the
licensed ACTCelerate technology and other technology sublicensed from
Lifeline. Embryome Sciences also plans to bring to market new growth and
differentiation factors that will permit researchers to manufacture
specific cell types from embryonic stem cells, and purification tools
useful to researchers in quality control of products for regenerative
medicine.
Additional information about ACTCellerate technology appears in the May
2008 edition of the journal Regenerative Medicine (www.futuremedicine.com/toc/rme/3/3).
ACTCellerate™ is a trademark of Advanced Cell
Technology, Inc.
About BioTime, Inc. (BTIM.OB):
BioTime, headquartered in Alameda, California, develops blood plasma
volume expanders, blood replacement solutions for hypothermic (low
temperature) surgery, organ preservation solutions, and technology for
use in surgery, emergency trauma treatment and other applications.
BioTime's lead product Hextend is manufactured and distributed in the
U.S. by Hospira, Inc. and in South Korea by CJ Corp. under exclusive
licensing agreements. BioTime has recently entered the field of
regenerative medicine through its wholly owned subsidiary Embryome
Sciences, Inc. where it plans to develop new medical and research
products using embryonic stem cell technology. Additional information
about BioTime can be found on the web at www.biotimeinc.com.
Hextend®, PentaLyte®,
HetaCool®, EmbryomicsTM,
ESpyTM, and ESpanTM
are trademarks of BioTime, Inc.
Forward-Looking Statements Statements pertaining to future financial and/or operating results,
future growth in research, technology, clinical development and
potential opportunities for the company and its subsidiary, along with
other statements about the future expectations, beliefs, goals, plans,
or prospects expressed by management constitute forward-looking
statements. Any statements that are not historical fact (including, but
not limited to statements that contain words such as "will,” "believes,” "plans,” "anticipates,” "expects,” "estimates,”)
should also be considered to be forward-looking statements.
Forward-looking statements involve risks and uncertainties, including,
without limitation, risks inherent in the development and/or
commercialization of potential products, uncertainty in the results of
clinical trials or regulatory approvals, need and ability to obtain
future capital, and maintenance of intellectual property rights. Actual
results may differ materially from the results anticipated in these
forward-looking statements and as such should be evaluated together with
the many uncertainties that affect the company's business, particularly
those mentioned in the cautionary statements found in the company's
Securities and Exchange Commission filings. The company disclaims any
intent or obligation to update these forward-looking statements.
To receive ongoing BioTime corporate communications, please click on the
following link to join our email alert list: http://www.b2i.us/irpass.asp?BzID=1152&to=ea&s=0
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