DGAP-Stimmrechtsanteile: SYGNIS AG

DGAP-PVR: SYGNIS AG: Release according to Article 26, Section 1 of the WpHG [the German Securities Trading Act] with the objective of Europe-wide distribution

SYGNIS AG

24.12.2015 19:30

Dissemination of a Voting Rights Announcement, transmitted by DGAP - a service of EQS Group AG. The issuer is solely responsible for the content of this announcement. ---------------------------------------------------------------------------

Notification of Major Holdings

1. Details of issuer

SYGNIS AG Waldhofer Str. 104 69123 Heidelberg Germany

2. Reason for notification

Acquisition/disposal of shares with voting rights Acquisition/disposal of instruments X Change of breakdown of voting rights Other reason:

3. Details of person subject to the notification obligation

Name: City and country of registered office: Genetrix S.L. Madrid Spain

4. Names of shareholder(s) holding directly 3% or more voting rights, if different from 3.



5. Date on which threshold was crossed or reached

16.12.2015

6. Total positions

% of voting % of voting rights total of total number rights attached through instruments both in % of voting to shares (total (total of 7.b.1 + (7.a. + rights of of 7.a.) 7.b.2) 7.b.) issuer Result- 12,61 % 16,76 % 29,37 % 16457486 ing situat- ion Previo- 15,38 % 20,44 % 35,82 % / us notifi- cation

7. Notified details of the resulting situation a. Voting rights attached to shares (Sec.s 21, 22 WpHG)

ISIN absolute in % direct (Sec. indirect (Sec. direct (Sec. indirect 21 WpHG) 22 WpHG) 21 WpHG) (Sec. 22 WpHG) DE000A1RFM03 2075558 0 12,16 % 0 % Total 2075558 12,16 %

b.1. Instruments according to Sec. 25 Abs. 1 Nr. 1 WpHG

Type of instrument Expiration Exercise or Voting Voting or maturity conversion rights rights date period absolute in % Rueckuebertragungsanspr- 18.12.2015 18.12.2015 2758340 16,76 % uch aus einem Darlehensvertrag Total 2758340 16,76 %

b.2. Instruments according to Sec. 25 Abs. 1 Nr. 2 WpHG

Type of Expiration Exercise or Cash or Voting Voting instrume- or maturity conversion physical rights rights nt date period settlement absolute in % % Total %

8. Information in relation to the person subject to the notification obligation

X Person subject to the notification obligation is not controlled and does itself not control any other undertaking(s) holding directly or indirectly an interest in the (underlying) issuer (1.). Full chain of controlled undertakings starting with the ultimate controlling natural person or legal entity:

Name % of voting rights % of voting rights Total of both (if (if at least held 3% through instruments (if at least held 5% or more) at least held 5% or more) or more)

9. In case of proxy voting according to § 22 Abs. 3 WpHG

Date of general meeting: Holding position after general meeting: % (equals voting rights)

24.12.2015 The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases. Media archive at www.dgap-medientreff.de and www.dgap.de

--------------------------------------------------------------------------- Language: English Company: SYGNIS AG Waldhofer Str. 104 69123 Heidelberg Germany Internet: www.sygnis.com End of Announcement DGAP News-Service ---------------------------------------------------------------------------